Projekt Brno Ph.D. Talent

Roberto Pivato

Modeling The Cardiac Progenitor Depletion Induced Heart Failure In Patients Suffering Duchenne Muscular Dystrophy Using Human Induced Pluripotent Stem Cells

Školitel: Mgr. Vladimir Rotrekl, PhD.

Instituce: Masaryk University, Faculty of Medicine

Obor: Biomedical sciences- Biochemistry and Molecular Biology


O projektu

Duchenne muscular dystrophy (DMD) is a genetic disease affecting males and resulting in severe skeletal muscle fibrosis affecting also the heart and leading to premature death. We hypothesize that depletion of cardiovascular progenitors hampers heart homeostasis. The purpose of this project is to model the depletion of cardiovascular progenitors using human induced pluripotent stem cells from DMD patients, understand the molecular mechanisms behind it and correct these mechanisms.


Kde se profesně vidím za 10 let



Proč mám rád/a Brno