Unraveling a SUMO-mediated regulation of brc-1/brca1 functions during gametogenesis
Školitel: Dr. Nicola Silva, PhD.
Instituce: Masaryk University, Faculty of Medicine
Obor: Biomedical sciences- Biochemistry and Molecular Biology
Duchenne muscular dystrophy (DMD) is a genetic disease affecting males and resulting in severe skeletal muscle fibrosis affecting also the heart and leading to premature death. We hypothesize that depletion of cardiovascular progenitors hampers heart homeostasis. The purpose of this project is to model the depletion of cardiovascular progenitors using human induced pluripotent stem cells from DMD patients, understand the molecular mechanisms behind it and correct these mechanisms.
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