Jan Česnek

Exploring Alzheimer’s disease and drug screening through in vitro models of neuronal membranes

Lector: prof. RNDr. Zbyněk Prokop, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Environmental Health Sciences: Computational Biology, Bioinformatics and Modelling

 

About the project

Alzheimer’s disease (AD) is the most common cause of dementia and a global socio-economic issue. This project investigates interactions of Aß42 and ApoE – key protein drivers of AD pathogenesis – with lipid membranes using innovative microfluidic membrane models. By combining high-throughput biophysical assays with in vitro candidate screening, the project aims to provide molecular mechanistic insights into the pathological processes of AD and accelerate the discovery of novel AD therapeutics.

 

Why science?

I find it inspiring how science gradually uncovers and explains the remarkable processes that govern nature and the human body. Research is wonderfully varied and never lets you fall into a routine. I especially enjoy those moments when a successful experiment yields intriguing data that fit together logically and cohesively. Interpreting such findings can move our understanding forward and indirectly help many people, which I see as essential.

 

What do I like most about Brno

Brno is a very pleasant city not only to work in, but also to live in – it’s big enough to offer plenty of opportunities, yet compact enough that everything is within easy reach. Science, food, culture and infrastructure are all at a very good level here. Personally, I most enjoy the city’s summer atmosphere and its local cafés tucked away in cosy corners.