Brno Ph.D. Talent
Brno Ph.D. Talent
Targeting the DSG2–MMP14 Axis to Overcome Metastasis Progression and Therapy Resistance
Lector: doc. Mgr. Karel Souček, Ph.D.
Institution: Masaryk University, Faculty of Science
Field: Animal physiology, immunology and developmental biology
About the project
My project focuses on the interplay between the adhesion molecule Desmoglein-2 (DSG2) and the enzyme MMP14 in driving cancer metastasis. We observed that the loss of DSG2 not only disrupts cell-to-cell contact but also triggers MMP14-mediated remodeling of the extracellular matrix, facilitating tumor invasion. By understanding this mechanism, I aim to validate the DSG2-MMP14 axis as a potential therapeutic target, which could lead to new strategies for suppressing metastatic progression.
Why science?
I chose science because it is a field that never stands still. I enjoy the constant challenge of solving complex puzzles and the necessity to keep learning every day. Working in cancer research gives my work a deeper purpose—it is not just about data, but about understanding the intricate ways tumor cells adapt and finding the specific vulnerabilities we can target to fight the disease.
What do I like most about Brno
For me, Brno has the perfect balance. It is a dynamic city full of students, great coffee, and culture, yet it remains compact and friendly. Scientifically, it offers a supportive community and cutting-edge facilities that rival those in larger cities. I appreciate that I can work on high-level research during the day and enjoy the lively city center with friends in the evening.