Brno Ph.D. Talent
Brno Ph.D. Talent
Development of a Structure-Based Drug Design Strategy for the Discovery of Novel Therapeutics in Alzheimer’s Disease
Lector: doc. Mgr. David Bednář, Ph.D.
Institution: Masaryk University, Faculty of Science
Field: Environmental Health Science
About the project
Alzheimer's disease affects millions, yet despite decades of research we still lack effective therapies. Apolipoprotein E (ApoE) is one of potentially promising therapeutic targets; however, its structural properties render it challenging for traditional computational strategies. This project aims to develop an innovative computational workflow to overcome these limitations and thus enable identification of promising drug candidates against Alzheimer's disease.
Why science?
My scientific journey began with childhood curiosity about nature, evolving into a passion for chemistry and biology in high school. I'm drawn to science because it's intellectually challenging and collaborative—the community remains open and supportive despite fierce competition. Most importantly, working with brilliant and inspiring colleagues and the real chance of meaningful contribution to society make science the best field I can imagine.
What do I like most about Brno
Brno is my home in every sense—the city where I was born, where I completed my entire education, and where I continue to build my career. I've never felt the need to seek opportunities elsewhere because Brno has consistently provided everything essential for my personal and professional life: excellent educational institutions, a vibrant cultural scene, and a strong community of colleagues, friends, and family.