Tim de Martines

Advanced Protein Profiling and Rational Engineering of Next-generation Therapeutics for Ischaemic Stroke

Lector: doc. Mgr. David Bednář, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Environmental Health Sciences

 

About the project

In order to provide improved treatment modalities for stroke patients, this project aims to perform rational protein engineering on a promising new thrombolytic, staphylokinase. I will design diverse variants, which will be computationally filtered, allowing for exploration of the mutational space whilst maintaining feasibility in their validation. Additionally, I will employ advanced in silico methods to deepen our understanding of the active protein complex for targeted protein engineering.

 

Why science?

I enjoy methodically tackling complex problems by breaking them into smaller, manageable components and working collaboratively to solve them. Science provides an environment where this approach is not only encouraged but essential. Additionally, knowing that my research can provide tangible value to others, such as improved medical outcomes, gives my work purpose and makes it deeply fulfilling.

 

What do I like most about Brno

Having lived in several different countries and cities, Brno is the first one that has felt like home. It is a perfect size, offering access to all you need without being colossal. Moreover, the people are friendly, there is a lot to do, and it is just a short travel to many tourist sites. I equally greatly appreciate the highly collaborative nature of science here, allowing me to fully explore opportunities.