Brno Ph.D. Talent

David Zimčík

SATB2 as a Key Molecule Driving Developmental, Pathological, and Regeneration Processes of teeth

Lector: Assoc. Prof. RNDr. Marcela Buchtová, Ph.D

Institution: Masaryk University, Faculty of Science

Field: Animal physiology, immunology and developmental biology


About the project

My goal is to study tooth formation and changes in tooth tissues after injury. I am investigating activated and silenced genes during regeneration with a focus on SATB2, a key regulator. Shutting down SATB2 leads to remarkable changes in tooth development. Unraveling these mechanisms will aid in the development of targeted treatments.I am actually trying to "hack" the healing mechanisms and shut down the unwanted processes that accompany the healing after injury.


Why science?

Science is a tool that allows us to understand everything around us and within ourselves better. I enjoy how a simple question often evolves over time into a complex problem. Solving it requires the collaboration of many people, and the result can bring not only useful knowledge but also a new experience, friends and interesting experiments. My great motivation is the desire to one day communicate complex topics in an understandable way and to excite the next generation about scientific work.


What do I like most about Brno

For me, Brno is a combination of nature and the scientific environment. It suits me that Brno is not very big, but it is still a centre of many scientific activities. With plenty of green parks and forests around, it offers a pleasant escape from the hustle and bustle of the city. The great thing is that it is easy to get anywhere by bike, and everything is also reachable by public transport within a short time.