Brno Ph.D. Talent

Soňa Kadáková

Using a human pluripotent stem cell-based model to study the Alzheimer's disease pathogenesis in vitro

Lector: Mgr. Dáša Bohačiaková, Ph.D.

Institution: Masaryk University, Faculty of Medicine

Field: Biomedical Sciences - Cell and Tissue Morphology


About the project

Alzheimer's disease (AD) is a neurodegenerative disorder. Currently, induced pluripotent stem cells (iPSCs) are used to study human neurodevelopment. In the case of AD, iPSCs have been used to create cerebral organoids, which can adequately mimic AD in vitro. These models can also mimic the early development of the brain, and they can thus help to understand the initiation steps and molecular mechanisms of AD. This project aims to uncover mechanisms that lead to the development of AD.


Why science?

Working in science is a hobby for me, but at the same time a challenge. My curiosity and patience drive me forward to experiment and explore. On the other hand, science is often associated with the trial-and-effort method. The research does not always go the way we expect, nevertheless, it challenges me in the way of seeking other possibilities how to overcome the obstacles. The work of a scientist is like a roller coaster ride, but at the end of it a well-deserved reward awaits us.


What do I like most about Brno

I came to Brno to study at Masaryk University 6 years ago. Brno offers enormous possibilities not only in the work sphere, as the top laboratories and scientific teams led by top professionals in the field are there, but also in the sphere of social enjoyment. With Brno, it was clearly love at first sight.