Brno Ph.D. Talent

Linda Kašiarová

Translational stroke intervention through an engineered microbial thrombolytic agent: from atoms to patients

Lector: Ing. RNDr. Martin Marek, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Molecular and Cell Biology and Genetics


About the project

Cardio- and cerebrovascular diseases are leading causes of death and disability and one of the highest socio-economic burdens of any disease type. Staphylokinase is an attractive plasminogen activator of bacterial origin that forms complexes with plasmin, promoting the conversion of plasminogen into plasmin. The project is aimed to engineer the Staphylokinase through protein engineering methods to pave the way to next-generation of effective, highly selective, and less toxic thrombolytics.


Why science?

After completing my studies, I see myself as a part of a biotechnology company. I want to combine the challenges of fundamental research with the real life applications to actually see the impact that science has on our society.


What do I like most about Brno

Brno is a great combination of young and dynamic although still small and cozy city. It provides many opportunities regarding studying or career development as well as it is a great city for social life full of amazing people.