Brno Ph.D. Talent

Jakub Sumbal

Fibroblast-intrinsic FGF, WNT and NOTCH signaling in mammary epithelial morphogenesis.

Lector: Mgr. Zuzana Koledova, Ph.D.

Institution: Masaryk University, Faculty of Medicine

Field: Biomedical sciences/Developmental and Cell Biology


About the project

How organs are formed is a fundamental question of developmental biology. External signals from microenvironment are directive for organ development and similar growth-promoting cues are misemployed in cancer. I study how three major signaling pathways - FGF, WNT and NOTCH - regulate state and fate of fibroblasts, the leading cell type of the microenvironment. My findings will pave the way for novel microenvironment-targeted anti-cancer therapy.


Why science?

Everyday, I see things that no one has seen before! How cool is that?


What do I like most about Brno

Not too big, not too small and great cafés!