Brno Ph.D. Talent

Karolína Smolková

Targeting the eIF4F complex to overcome melanoma resistance to BRAF and MEK inhibitors

Lector: Mgr. Stjepan Uldrijan, CSc.

Institution: Masaryk University, Faculty of Medicine

Field: Biomedical Sciences


About the project

Metastatic melanoma is aggressive cancer, driven by oncogenic mutations in the ERK pathway. Inhibitors targeting its members are among the most effective drugs currently used for melanoma treatment. However, resistance usually appears. As it was linked to the drug resistance, enhanced eIF4F activity is a promising therapeutic target. In my project, I aim to provide mechanistic insight into the link between eIF4F and ERK signaling in melanoma, and identify and characterize new eIF4F inhibitors.


Why science?

Science is challenging in many ways, which pushes me forward, improving different skills. It is not monotonous and allows (and requires) creativity. Thanks to its international dimension it supports travelling and will not let you forget foreign languages. And I have wandering shoes a bit, and several months long internships abroad suit me. Taking this opportunity, in addition to an important professional experience, I can collect smaller or larger pieces of the host country culture as well.


What do I like most about Brno

Brno is not overly big, so almost everything is relatively close. All those cafés, tea rooms and bars make it cosy. The city offers something for everyone: diverse sports possibilities, a wide range of cultural experiences, and quiet locations for walks in nature.