Brno Ph.D. Talent

Lucie Curylová

The p53 family proteins in the regulation of stemness in pediatric sarcomas

Lector: RNDr. Jan Škoda, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Molecular and Cell Biology and Genetics


About the project

Sarcomas belong to the most common types of tumors in children. These tumors are highly aggressive and the survival rate of pediatric patients remains poor. Thus, there is a great need to find new efficient therapy. The role of p53 in the regulation of cancer stemness has been recently suggested. As p53 family proteins are often dysregulated in sarcomas, this project will investigate if these proteins may serve as therapeutic targets of new p53 reactivators to improve pediatric sarcoma outcomes.


Why science?

In 10 years, after finishing my PhD studies, I would like to attain a post-doc position in a renowned laboratory abroad and continue my research in the field of molecular oncology.


What do I like most about Brno

It is hard to tell what I like most because I fell in love with Brno as it is at the first sight and I would not change anything about it. I like its atmosphere of a big and a small town at the same time. Brno has become my new home.