Brno Ph.D. Talent

Andrea Martišová

New insight into molecular functions of AGR2 in colorectal cancer

Lector: Associate prof. Roman Hrstka, MSc., Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Biochemistry - Genomics and Proteomics


About the project

Even though the role of Anterior gradient 2 (AGR2) in carcinogenesis and metastatic formation has been reported, the precise molecular mechanisms remain still largely unclear. This project aims to i) elucidate the molecular reprogramming of AGR2 expression during metastasis, ii) clarify the molecular pathways associated with AGR2 in cell adhesion and iii) describe the role of AGR2 in regulating gene expression at the post-transcriptional level through RNA-protein interactions.


Why science?

In 10 years’ time, I plan to have my PhD studies successfully completed with at least one post-doctoral stay at a prestigious foreign institution. Hopefully, this will provide the amount of experience I wish to gain and make me the best version of a scientist I can be after these 10 years. Honestly, at this moment, I see my future self mostly gaining knowledge, experience and contacts abroad but once I am ready, I wish to have my own cancer research group.


What do I like most about Brno

That would be the combination of large city opportunities mixed with the perks of small-town life. Brno provides jobs, good universities, restaurants and past time activities on a city scale while at the same time you have everything relatively close with only a fraction of large crowds of people when compared with for instance Praha, or a bit exaggerated – London.