Brno Ph.D. Talent

Tomáš Brom

Molecular mechanism of glioblastoma cell differentiation – characterization of REST-TRF2 complex

Lector: doc. Mgr. Ctirad Hofr, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Genomics and Proteomics


About the project

Glioblastoma is the most common and malignant brain tumor in adults. So far, there has been no successful treatment. Recent studies revealed a strong correlation between glioblastoma tumorigenicity and the aberrant expression of REST, a main repressor of neural stem cells differentiation. Telomeric factor TRF2 protects REST from proteasomal degradation. REST-TRF2 complex disruption is a promising target of molecular therapy. We will identify and describe critical interactions of REST and TRF2.


Why science?

I would like to travel abroad after my successful gain of a Ph.D. title and get a Postdoc position on the respectful research institution. After gaining practical research experience and management knowledge from abroad, I would like to return to Brno and establish my own research group and help to raise a new generation of great Czech scientists.


What do I like most about Brno

I really like Brno because of several reasons. I am a huge fan of good coffee so I am happy that Brno offers advanced coffee culture, accompanied by great gastronomic and cultural background that is easily comparable with surrounding large cities (Vienna, Prague). Despite that Brno keeps a small city atmosphere. Another advantage of Brno is that everything is situated in the distance easily reachable by bike or by public transport.