Brno Ph.D. Talent

Sandra Thalerová

On chip models to determine mechanisms of limitations of alteplase induced thrombolysis

Lector: Mgr. Jan Víteček, Ph.D.

Institution: Masaryk University, Faculty of Science

Field: Biochemistry


About the project

Stroke is the second most important cause of mortality worldwide. Although intravenous thrombolysis using recombinant tissue plasminogen activator (alteplase) presents clinically approved treatment method its efficacy is limited. The proposed project focuses on establishment of on chip models to study alteplase efficacy and identification of mechanisms of its limitation. This way the project can provide the groundwork for future improvement of thrombolytic therapy.


Why science?

My intention is to stay in the area of life science research, preferably in the field of hematology. In 10 years, I expect to lead, as a senior researcher at the research center, a smaller research team, considering my specializations in the field of vascular modeling and biochemistry on a chip. I assume that during this time I will take part in a number of international internships and conferences and publish several articles.


What do I like most about Brno

Brno offers great facilities for students and graduates, not only academically, but also in cultural life, as well as in the availability of housing for young people.