Brno Ph.D. Talent

Laura Ondrišová

Migration of Leukemia B Cells and Their Adaptive Response to BCR Inhibitor Therapy

Lector: Assoc. Prof. Marek Mraz, MSc., MD, PhD.

Institution: Masaryk University, Faculty of Medicine

Field: Experimental Oncology and Tumor Biology


About the project

Inhibitors of B-cell receptor (BCR) signalling pathway have been recently introduced in the treatment of chronic lymphocytic leukemia (CLL). Despite a good initial clinical response, CLL cells are able to survive still after months of continuous therapy. My project is focused on finding such mechanisms of adaptation that allow CLL cells to survive under the treatment and use this knowledge to identify novel therapeutical targets for more sufficient combinatory therapy of CLL.


Why science?

I would like to still be in research. After my PhD studies, I plan to spent some time working abroad as a post-doc in a worldly-renowned research facility. Whether I come back to Brno or stay abroad, I hope to once be a leader of my own research group.


What do I like most about Brno

I love the student-friendly atmosphere of Brno. I am also very grateful for all the professional opportunities that Brno has to offer to a young scientist like me.