Miroslav Hutňan

NO synthase as a potential target for improved heart function in patients suffering from Duchenne muscular dystrophy

Školitel: Vladimír Rotrekl

Instituce: Masaryk University, Faculty of Medicine

Obor: Medical Biology

 

O mém projektu

Our preliminary data and literature indicate there might be a yet unknown link between dilated cardiomyopathy in patients suffering from Duchenne muscular dystrophy and dystrophin. In this project, I want to evaluate this link, identified as NO synthase, as a possible target of inhibition and its potential to reduce genomic instability and improve heart function through influencing cardiomyocyte progenitor population and increasing their differentiation efficiency into mature cardiomyocytes.