Interaction of receptor tyrosine kinases with primary cilia in health and disease
Školitel: Mgr. Pavel Krejci, PhD
Instituce: Masaryk University, Faculty of Medicine
Obor: Medical Biology
O mém projektu
A diverse array of ion channels, cell surface receptors and downstream signaling proteins have been found to localize and exert functions in the primary cilia, therefore allowing the cilium to receive and transduce extracellular signals. Several lines of evidence suggest, that the cilium plays a key regulatory function in many cellular processes, either by spatial compartmentalization of the signaling molecules, or precise fine-tuning of their action. Deregulation of cellular signaling caused by defects in ciliary assembly or function, has been associated to numerous developmental disorders and diseases. Therefore, a systematic study focused on identification of signaling molecules functioning in the primary cilia, and the biological relevance of such localization is of high demand. In this study, the focus would be on one group of the signaling molecules – the receptor tyrosine kinases (RTKs) – and their association with primary cilia in health and disease. Out of 58 existing members of the RTK family, only two members – PDGFRA and IGF1R – have been systematically studied and their signaling tightly linked with primary cilia. The evidence associating other RTKs with cilia is virtually missing, despite its high potential in addressing many human diseases.