Václav Chochola

Modelling lung tissue in vitro by 3D bioprinting

Školitel: Ing. Josef Jaroš, Ph.D.

Instituce: Masaryk University, Faculty of Medicine

Obor: Anatomy, Histology and Embryology

 

O mém projektu

Recent techniques of planar cultivation and manipulation with stem/progenitor cells in vitro lack the possibilities of 3D arrangement of cells. These are crucial for creating biological models of tissues/organs with complex hierarchy and spatial combination of different cell types. Development of such tissue models can be achieved by combination of 3D bioprinting technology with functionalized hydrogels, human airway alveolar progenitors and endothelial precursors. In this project we aim to uncover conditions and factors that drive morphogenesis of highly structured (branched) organ – human lungs.