Application of plasma polymers on nanofibrous mats for tissue replacement therapies
Školitel: Assoc. Prof. Mgr. Lenka Zajíčková, Ph.D.
Instituce: Masaryk University, Faculty of Science
Obor: Physiology of Animals
O mém projektu
For many years, it has been an effort of tissue engineering to develop tissue replacements that would be natural to the body, absorbed spontaneously and be a carrier of appropriate cells. Synthetic polymers modified by relatively simple, economically and ecologically suitable plasmachemical processes, making them a suitable carrier for the cells are gradually gaining popularity. This project is about optimalization of plasma treatment of polycaprolactone fibres. Polycaprolactone nanofibres and standard polystyrene Petri dishes are coated with non-toxic cyclopropylamine, which leads to the formation of layers rich in positively charged amine groups. The aim of this research is to determine the effect of such functionalized surfaces on different types of cells, but primarily on vasculoendothelial cells, as prime goal is to get results that could lead to development of proper vascular replacements, which can help in the treatment of many injuries and diseases of the vascular system.