Filip Melicher

Structural determination of lectins from Photorhabdus spp.

Školitel: prof. RNDr. Michaela Wimmerová, Ph.D.

Instituce: Masaryk University, CEITEC MU

Obor: Structural Biology

 

O mém projektu

Lectins are proteins with the ability to recognize and reversibly bind mono- and oligosaccharides. These sugar-binding proteins exhibit various functions and they are involved in many biological processes. This project is focused on the structural characterisation of lectins from insect and human bacterial pathogens of Photorhabdus spp. and their complexes with binding partners. Structural characterisation of the proteins will be performed by protein crystallography and cryo-electron microscopy.