Martin Toul

Rational protein design driven by advanced kinetics

Školitel: prof. RNDr. Zbyněk Prokop, Ph.D.

Instituce: Masaryk University, Faculty of Science

Obor: Molecular and Cellular Biology


O mém projektu

Within the project, advanced methods of transient kinetics will be used for characterization and engineering of selected protein molecules. The study will be focused on (i) Renilla luciferase and its ancestor exhibiting an extraordinary evolutionary history, and (ii) alteplase being used in pharmacy as a thrombolytic drug. The project aims to deeply understand the process of evolution at a molecular level (basic research), and to develop a new variant of the thrombolytic drug (applied research).