Aliaksei Chareshneu

Allosteric regulation and structural bioinformatics of nicotinic acetylcholine receptors

Školitel: Jaroslav Koča

Instituce: Masaryk University, Faculty of Science

Obor: Biomolecular Chemistry

 

O mém projektu

Nicotinic acetylcholine receptors (nAChRs) are large proteins that relay signals at neural or neuromuscular junctions by transferring ions across the cellular membrane. NAchR function is mediated by allostery, a phenomenon involving a network of information transfer across the protein. In this project, I will employ novel computational tools to characterize allosteric regulation in nAchRs at the level of amino acid residues, which will be helpful in designing drugs for modulating nAChR activity