DNA Damage and Repair
Školitel: RNDr. Petr Kulhánek, Ph.D.
Instituce: Masaryk University, Faculty of Science
Obor: Biomolecular Chemistry
O mém projektu
Understating mechanism of DNA repair can help in design of novel anticancer therapies. Employing molecular modeling we will decipher molecular mechanisms of DNA mismatch recognition by the MutS enzyme. Next, we will improve force field parameters providing better assessment of binding affinities of anticancer drug-carrier complexes. Combining results from these two subprojects, we will try to improve selectivity of anticancer drugs by targeting mismatches.