Ivo Durník

DNA Damage and Repair

Školitel: RNDr. Petr Kulhánek, Ph.D.

Instituce: Masaryk University, Faculty of Science

Obor: Biomolecular Chemistry


O mém projektu

Understating mechanism of DNA repair can help in design of novel anticancer therapies. Employing molecular modeling we will decipher molecular mechanisms of DNA mismatch recognition by the MutS enzyme. Next, we will improve force field parameters providing better assessment of binding affinities of anticancer drug-carrier complexes. Combining results from these two subprojects, we will try to improve selectivity of anticancer drugs by targeting mismatches.