Veronika Šmídová

DISCOVERING THE MOLECULAR PATHWAYS RESPONSIBLE FOR CHEMORESISTANCE TO TYROSINE KINASE INHIBITORS

Školitel: Mgr. Zbyněk Heger, Ph.D.

Instituce: Mendel University in Brno, Faculty of AgriSciences

Obor: Chemistry

 

O mém projektu

This project aims to reveal the cellular communication network responsible for development of chemoresistance to tyrosine kinase inhibitors. Pivotal point is development of a model of tumour cell lines with acquired chemoresistance to selected TKIs. Using this model, I would like to study transcriptome and deep proteome with consequent functional silencing analyses that would potentially lead to characterization of therapeutically beneficial biomacromolecules useable for inhibiting cancer chemoresistance.