DISCOVERING THE MOLECULAR PATHWAYS RESPONSIBLE FOR CHEMORESISTANCE TO TYROSINE KINASE INHIBITORS
Školitel: Mgr. Zbyněk Heger, Ph.D.
Instituce: Mendel University in Brno, Faculty of AgriSciences
O mém projektu
This project aims to reveal the cellular communication network responsible for development of chemoresistance to tyrosine kinase inhibitors. Pivotal point is development of a model of tumour cell lines with acquired chemoresistance to selected TKIs. Using this model, I would like to study transcriptome and deep proteome with consequent functional silencing analyses that would potentially lead to characterization of therapeutically beneficial biomacromolecules useable for inhibiting cancer chemoresistance.