Pavlína Pokorná

Structure and Dynamics of Protein-Protein and Protein-RNA Recognition

Školitel: Prof. RNDr. Jiří Šponer, DrSc.

Instituce: Masaryk University, Faculty of Science

Obor: Biomolecular Chemistry

 

O mém projektu

Atomic-level structural-dynamics of several biologically significant protein-RNA and protein-protein complexes will be studied using molecular dynamics simulations. The goal is to determine key residues for biomolecular recognition and to understand roles of specific mutations and epigenetic modifications with emphasis on dynamical aspects of the recognition, which are not apparent using commonly used experimental methods. The project will also contribute to the method testing and development.