Optimization of colorectal carcinoma targeted therapy by enhancing the penetration and cytotoxicity of cell signaling regulators
Školitel: doc. Mgr. Petr Beneš, Ph.D.
Instituce: Masaryk University, Faculty of Science
Obor: Molecular and Cell Biology
O mém projektu
Colorectal carcinoma (CRC) is one of the most common cancer diseases in the Western countries, but there still is no reliable therapy. Strategies combinating the standard chemotherapy and targeted treatment will be used in this project. The study aims to determination of chemotherapeutics penetration and their degradation products in 3D models of tumor tissue by MALDI-MSI and to evaluation of targeted chemotherapy LOX inhibitors effect on tumor cell migration/ invasiveness in 3D models of tumor tissue.