MUS81 INHIBITORS AS TOOL COMPOUNDS FOR ELUCIDATION OF MUS81 FUNCTION IN MAINTAINING GENOME INTEGRITY WITH THERAPEUTIC POTENTIAL
Školitel: Dr. Lumír Krejčí
Instituce: Masaryk University, Dr. Lumír Krejčí
Obor: Biomolecular Chemistry
O mém projektu
Cancer cells are often mutated in certain DNA repair proteins and thus become dependent on other compensatory repair pathways for survival. Targeting these alternative pathways is a promising approach in cancer treatment. MUS81 plays an important role in processing various DNA intermediates and in this project we aim at characterizing MUS81 inhibitors to elucidate the role of MUS81 in maintaining the genome integrity and validate synthetic lethal/sick interactions with clinical relevancy.