Endoplasmic reticulum-associated mechanisms of tissue homeostasis
Školitel: Petr Vaňhara
Instituce: Masaryk University, Medicine
Obor: anatomy, histology and embryology
O mém projektu
This project should determine how the molecular state of ER and ER stress affects the biology, function and morphology of normal ovarian epithelial cells and ovarian tissues, including senescence, malignant transformation, transdifferentiation and reparative regeneration. ER stress molecular machinery is an important process affecting tissue homeostasis and there are still many uncertainties, such as the control of apoptosis pathways induced by ER stress in mammals and how these pathways could be used as a pharmacological target.