MYB and its signaling in control of osteosarcoma progression
Školitel: doc. Mgr. Petr Beneš, Ph.D.
Instituce: Masaryk University, Faculty of Science
Obor: Molecular and Cellular Biology
O mém projektu
Osteosarcoma (OS) is highly aggressive and the most common primary malignant bone tumor. Despite of progress in cancer treatment, therapy of OS is based on the drugs that have been used since 1970s. Our data mining and preliminary expression study revealed that protein c-Myb is heterogeneously expressed in OS tissue and that it is overexpressed in aggressive clones of OS cell lines. The aim of this project is to assess the function of c-Myb and its signaling in control of OS progression.