The Role of Adipokines Produced by Senescent Cells in the Onset and Development of Complex Diseases in Humans
Školitel: Assoc. Prof. MUDr. Julie Bienertová Vašků, Ph.D.
Instituce: Masaryk University, Faculty of science
Obor: Molecular and Cellular Biology
O mém projektu
Recent studies have clearly demonstrated that the selective elimination of senescent cells has beneficial effects on the life span and ameliorates the prognosis of many age-related diseases. However, the mechanisms by which senescent cells influence surrounding tissue are not yet fully understood. This project thus aims to characterize the metabolome and proteome of senescent preadipocytes and senescent-like adipocytes and investigate its effect on the development of complex diseases.