Václav Hejret

Cancer related gene analysis using modern long read sequencing for direct clinical diagnostics

Školitel: doc. RNDr. Radka Svobodová Vařeková, Ph.D.

Instituce: Masaryk University, Faculty of Science

Obor: Biomolecular Chemistry

 

O mém projektu

Cancer related genes are genes for which mutations have been causally implicated in cancer. One of the genes is Human Tumor protein TP53. Mutations of the TP53 gene are associated with more than 50% of human malignancies. MinION is a modern long-read sequencer with low price and easy sample preparation. Project focuses on analysis of TP53 mutations using long-read sequencing. Application of minION sequencing could provide new insights and help with faster and cheaper patient diagnostics.