Novel thiosemicarbazone iron chelators and their potential use in combined therapy of pediatric solid tumors
Školitel: prof. RNDr. Renata Veselská, Ph.D., M.Sc.
Instituce: Masaryk University, Faculty of Science
Obor: Molecular and Cell Biology
O mém projektu
Pediatric malignancies such as neuroblastoma or sarcoma often relapse and become resistant to multiple therapeutics. Thiosemicarbazones present a new category of drugs that show promising anti-cancer activity. Using the established and primary cell lines, this project aims to study mechanisms of anti-cancer therapy of thiosemicarbazones combined with low-molecular-weight inhibitors of signaling pathways. This may lead to creating new strategies for overcoming drug resistance in pediatric tumors.