Hana Svozilova

Modelling chronic lymphocytic leukemia in 3D

Školitel: Šárka Pospíšilová

Instituce: Masaryk University, Faculty of Medicine

Obor: Hematology

 

O mém projektu

The research of chronic lymphocytic leukemia (CLL) is complicated by the fact, that primary B cells from patients with CLL (B-CLL cells) undergo spontaneous apoptosis when cultivated in vitro. The aim of this research is to create a unique 3D model for long-term cultivation of primary B-CLL cells. Later the 3D cultivation system will be exposed to various treatments and proportions of remaining aberrant clones will be studied. This will help to better understand and predict the therapy response.